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KMID : 1123920050190020515
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Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 2 p.515 ~ p.519
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Genetic Polymorphism of Interleukin 10 Gene and Sasang Constitution in Bell’s Palsy Patients
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Kim Jong-Won
Seo Jung-Chul
Jung Tae-Young
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Abstract
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We hypothesized that the IL10 gene is important candidate in the development of Bell’s palsy and specific genotypic and allelic variations should be associated with Bell’s palsy in the Korean population. In this study, we assessed the SNP (single-nucleotide polymorphism) of IL10 in patients with Bell’s palsy. 62 patients with Bell’s palsy were selected from the subjects who visited for the Bell’s palsy service of the department of acupuncture & moxibustion, college of Oriental Medicine, Daegu Haany University from May 2002 to May 2003. Pyrosequencing was performed for genetic analyses. There was no statistically significant genotypic distribution difference between control and Bell’s palsy group And there was not statistically significant allelic frequency difference between control and Bell’s palsy group. In this study the IL10 genotypemight not be the risk factor of Bell’s palsy patients in Korean. studies will be necessary for the exact genetic markers. Establishment of more systemic approach and high quality of prospective cohorts will be necessary for the good prediction of genetic markers.
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KEYWORD
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Single Nucleotide Polymorphisms (SNP), Bell’s Palsy, Interleukin 10 (IL10), Sasang Constitution, minisequencing
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